Curse Rooms and Secret Rooms are more likely to pay off if they contain an item.However, if the player is going to The Chest, it may be worth holding on to The Dice to reroll the items in the Golden Chests. It's usually recommended to exchange The Dice for another activated item before going to fight Mom in the The Depths 2 as the floors after it don't have Shops or Item Rooms.Use The Dice for stat increases instead of trading it for other items on the first floor.This doesn't apply for Mom as you can't exit her room after beating her (unless carrying Teleport!, Cursed Skull, 0 The Fool Tarot Card, Hermit Tarot Card, The Stars Tarot Card, The Moon Tarot Card, IV The Emperor, or a Telepill). The earlier you find the Boss Room, Treasure Room or the Shop, the better as it allows more chances to reroll the items.
"Rerolling" doesn't mean that you'll always get a better item.The Ankh will allow Isaac to turn into ? if he dies, even if you haven't unlocked him. Simply die before you fight Mom's Heart/ It Lives!, kill them as ?, and The Dice will be unlocked. If you are shooting for the D6, but do not want to have to beat all of the floors as ?, try to find the Ankh item.However, note that the Angel Room essentially has only two or three "bad" items ( The Bible and the Prayer Card, if you want to hold on to the Dice), so bringing a fully charged dice into the Angel Room almost guarantees a good item (since if you get one of those items you can just reroll it). For advanced players, it's not as risky to make a deal in the Devil Room early on as with most of the other playable characters due to relatively high starting health.Isaac gains a very distinctive advantage when he obtains The Dice. Isaac's strength lies in his relatively high starting health but his other stats are average.
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